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Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline

Identifieur interne : 000351 ( France/Analysis ); précédent : 000350; suivant : 000352

Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline

Auteurs : F. Trigalo [France] ; R. Joyeau [France] ; V. C. Pham [France] ; J. J. Youté [France] ; P. Rasoanaivo ; F. Frappier [France]

Source :

RBID : Hal:hal-00016012

Abstract

The syntheses of three malagashanine analogues are reported. They involve conversion of strychnobrasiline in multiple steps and obtaining (i) unsaturation of the bond 3-14, (ii) inversion of configuration on carbon C3, (iii) inversion of configuration on carbon C3 and reduction of the benzene ring.


Url:
DOI: 10.1016/j.tet.2004.04.068


Affiliations:


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Hal:hal-00016012

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