Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline
Identifieur interne : 000351 ( France/Analysis ); précédent : 000350; suivant : 000352Synthesis of modulators of chloroquine resistance in Plasmodium falciparum, analogues of malagashanine from strychnobrasiline
Auteurs : F. Trigalo [France] ; R. Joyeau [France] ; V. C. Pham [France] ; J. J. Youté [France] ; P. Rasoanaivo ; F. Frappier [France]Source :
- Tetrahedron [ 0040-4020 ] ; 2004-06-14.
Abstract
The syntheses of three malagashanine analogues are reported. They involve conversion of strychnobrasiline in multiple steps and obtaining (i) unsaturation of the bond 3-14, (ii) inversion of configuration on carbon C3, (iii) inversion of configuration on carbon C3 and reduction of the benzene ring.
Url:
DOI: 10.1016/j.tet.2004.04.068
Affiliations:
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Hal:hal-00016012Le document en format XML
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<front><div type="abstract" xml:lang="en"> <p>The syntheses of three malagashanine analogues are reported. They involve conversion of strychnobrasiline in multiple steps and obtaining (i) unsaturation of the bond 3-14, (ii) inversion of configuration on carbon C3, (iii) inversion of configuration on carbon C3 and reduction of the benzene ring.</p>
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